Toxic proteins linked to Alzheimer’s

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Rashik Ahmed, lead author and PhD candidate in the Department of Biochemistry and Biomedical Sciences and Giuseppe Melacini, senior author and a professor in the Departments of Chemistry and Chemical Biology Credit: Georgia Kirkos, McMaster University

A TEAM of researchers from McMaster University has mapped at atomic resolution a toxic protein linked to Alzheimer’s disease, allowing them to better under- stand what is happening deep within the brain during the earliest stages of the disease.The findings, published on the front cover of the current edition of the Royal Society of Chemistry flagship journal Chemical Science, provide new insights into the behavior of one of the prime suspects of Alzheimer’s disease: a protein fragment known as amyloid beta, which clumps together into oligomers during the early stages of the disease.