SCIENTISTS have demonstrated how cells of a human intestinal lining created outside an individual’s body mirror living tissue when placed inside microengineered Intestine-Chips, opening the door to personalised testing of drug treatments.
The findings have the potential to change how patients are treated for debilitating, inflammatory gastrointestinal diseases with a genetic component, such as Crohn’s disease,
ulcerative colitis and irritable bowel syndrome.
Instead of exposing a patient to drug treatments that may be costly, ineffective or carry harmful side effects, scientists could use the individual’s own stem cells to produce a duplicate of the intestinal lining on an Intestine-Chip and test multiple drugs on it. Scientists then could determine which drug worked best on that patient’s intestine.
The study was conducted by investigators at the Cedars-Sinai Board of Governors Regenerative Medicine Institute and Emulate, Inc. in Boston.